姓名
张媛媛
单位部门
信息与控制工程学院/公共基础教研室
职称
副教授
电话/邮箱
yyzhang1217@163.com
个人简介
张媛媛,副教授,中国石油大学(华东)地质资源与地质工程流动站博士后,CCF和CAA会员。主要研究方向为机器学习等在生物组学数据和复杂疾病中的应用,基于人工智能的智慧医疗等方面的研究。现任公共基础教研室主任,主持国家自然科学青年基金1项,山东省自然科学基金1项,作为主要参与人参与国家自然科学基金2项、山东省自然科学基金2项,高等学校博士学科点专项科研基金1项。发表SCI论文20余篇,影响因子总和超30,其中以第一和通讯作者发表SCI论文7篇。主要承担大学计算机,程序设计基础(C语言),离散数学等理论教学任务。荣获山东省信息化教学比赛二等奖1项,校青年讲课比赛二等奖1项,校“三八红旗手”称号。
研究领域
1.计算生物信息学
2.机器学习
3.生物组学数据挖掘
4.网络表示学习
教科研情况
课程教学:
本科课程:《大学计算机》、《程序设计基础A(C语言)》、《离散数学》
研究生课程:《大数据技术》
主要科研项目:
1.国家自然科学基金,样本特异性基因功能模块挖掘的多源信息融合方法研究,23万,在研,主持;(2020.01-2022.12)
2.山东省自然科学基金,基于数据特征整合的差异甲基化模式识别方法研究,5万,在研,主持;(2018.03-2020.06)
3.山东省自然科学基金,基于机器学习与小波变换融合的复杂储层特征识别研究,5万,在研,第二参与人;(2019.07-2022.06)
4.山东省自然科学基金,基于统计学习的模式分布分析算法在高维复杂数据中的应用,15万,在研,第一参与人;(2019.07-2022.06)
5.国家自然科学基金,基于新一代测序数据的肿瘤纯度及倍体动态预测方法研究,60万,在研,第四参与人;(2016.01-2019.12)
6.国家自然科学基金,复杂基因逻辑网络若干理论和应用研究,59万,结题,第六参与人。(2012.01-2015.12)
学术成果
代表性论文:
1.Shudong Wang, Lihua Wang,Yuanyuan Zhang*,Shanchen Pang, Xinzeng Wang. PEIS: a novel approach of tumor purity estimation by identifying information sites through integrating signal based on DNA methylation data. BMC bioinformatics. 2019, 20 (s20) :714.(SCI, IF=2.511, JCR:2)
2.Yuanyuan Zhang*, Chuanhua Kou, Shudong Wang, Yulin Zhang.Genome-wide differential-based analysis of the relationship between DNA methylation and gene expression in cancer. Current Bioinformatics, 2019, 14: 783-792.(SCI, IF=1.189, JCR: 4)
3.Yuanyuan Zhang*, Shudong Wang, Xinzeng Wang.Data-Driven-Based Approach to Identifying Differentially Methylated Regions Using Modified 1D Ising Model. BioMed Research International. Volume 2018, Article ID 1070645, 8 pages, 2018. (SCI, IF: 2.583, JCR: 3)
4.Yuanyuan Zhang, Junying Zhang*, Junliang Shang.Quantitative identification of differentially methylated loci based on relative entropy for matched case-control data. Epigenomics-UK. 5(6): 631-643, 2013.(SCI, IF:5.215, JCR: 1)
5.Yuanyuan Zhang, Junying Zhang*.Identification of functionally methylated regions based on discriminant analysis through integrating methylation and gene expression data. Molecular BioSystems.11(7):1786-1793,2015.(SCI, IF:3.183, JCR: 3)
6.Yuanyuan Zhang, Junying Zhang*, Zhaowen Liu, Yajun Liu, Shouheng Tuo. A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression. Biochemical and Biophysical Research Communications (BBRC). 465(3): 437-442, 2015. (SCI, IF:2.297, JCR: 3)
7.Shudong Wang, Xinzeng Wang ,Qifang Song,Yuanyuan Zhang. High-Order Degree and Combined Degree in Complex Networks. Mathematical Problems in Engineering. Volume 2018, Article ID 4925841, 12 pages. 2018.(SCI, IF: 1.145, JCR:3)
8.Yajun Liu, Junying Zhang, Aimin Li,Yuanyuan Zhang, Yaoyao Li, Xiguo Yuan, Zongzhen He, Zhaowen Liu. Identification of PIWI-interacting RNA modules by weighted correlation network analysis. Cluster Computing, 2017.(SCI, IF: 2.04, JCR: 4)
9.Shouheng Tuo, Junying Zhang*,Xiguo Yuan,Yuanyuan Zhang, Zhaowen Liu. FHSA-SED: Two-Locus Model Detection for Genome-Wide Association Study with Harmony Search Algorithm. PloS One, 11(3):e0150669, 2016.(SCI, IF: 2.806, JCR: 3)
10.Zhaowen Liu, Junying Zhang*, Xiguo Yuan, Baobao Liu, Yajun Liu, Aimin Li,Yuanyuan Zhang, Xiaohan Sun, Shouheng Tuo. Detecting Pan-cancer Conserved MicroRNA Modules from MicroRNA Expression Profiles across Multiple Cancers. Molecular BioSystems.11, 2227 - 2237, 2015.(SCI, IF: 3.183, JCR: 3)
奖励与荣誉
1.山东省信息化教学比赛二等奖
2.青岛理工大学青年讲课比赛二等奖
3.青岛理工大学校级“三八红旗手”