姓名
江明建
单位部门
软件工程教研室
职称
讲师
邮箱
jiangmingjianwork@163.com
个人简介
江明建,男,博士,硕士生导师,1991年生,2021年毕业于中国海洋大学,获博士学位,同年入职青岛理工大学软件工程专业担任专业教师。主要研究方向为基于深度学习的计算生物学、生物信息学。
研究领域
基于深度学习的蛋白质组学研究、基于深度学习的蛋白质-小分子相互作用预测研究等生物信息学和计算生物学相关研究。目前组内拥有4090GPU两块,3090GPU一块,用于组内学生的模型训练和学习。
教科研情况
研究方向为智能药物设计,主要工作为采用卷积神经网络、图卷积神经网络等深度学习方法进行生物信息学的研究,包括蛋白质结合位点预测、小分子-蛋白质相互作用预测以及蛋白质-蛋白质相互作用预测等。共发表相关SCI文章15篇,CCF-B类会议文章1篇,谷歌学术累计他引580余次,其中以第一作者发表SCI文章5篇,参与专利申请3项。
学术成果
1. 相关科研项目:
[1] 基于序列的蛋白质-小分子结合活性智能预测研究(ZR2022QF111),山东省自然科学基金青年项目,主持,15万元,2023.1.1-2025.12.31。
[2] 基于知识引导的癌症亚型药物推荐方法研究(ZR2023MF053),山东省自然科学面上项目,参与,10万元,2024.1.1-2026.12.31。
[3] 基于数据隐私保护的智能药物研发平台(2023KJ070),生物信息与安全创新团队,山东省高等学校“青创团队计划”,参与,2023。
2. 部分学术论文:
[1] Mingjian Jiang, Shuang Wang, Shugang Zhang, Wei Zhou, Yuanyuan Zhang and Zhen Li. (2022). Sequence-based drug-target affinity prediction using weighted graph neural networks. BMC genomics, 23(1), 1-17.
[2] Mingjian Jiang, Zhen Li, Yujie Bian and Zhiqiang Wei. (2019). A novel protein descriptor for the prediction of drug binding sites. BMC bioinformatics, 20(1), 1-13.
[3] Mingjian Jiang, Zhiqiang Wei, Shugang Zhang, Shuang Wang, Xiaofeng Wang and Zhen Li. (2019). FRSite: Protein drug binding site prediction based on faster R–CNN. Journal of Molecular Graphics and Modelling, 93, 107454.
[4] Mingjian Jiang, Zhen Li, Shugang Zhang, Shuang Wang, Xiaofeng Wang, Qing Yuan and Zhiqiang Wei (2020). Drug–target affinity prediction using graph neural network and contact maps. RSC Advances, 10(35), 20701-20712.
[5] Mingjian Jiang, Yunchang Shao, Yuanyuan Zhang, Wei Zhou and Shunpeng Pang. (2023). A deep learning method for drug-target affinity prediction based on sequence interaction information mining. PeerJ, 11, e16625.
[6] Zhen Li, Mingjian Jiang, Shuang Wang and Shugang Zhang. (2022). Deep learning methods for molecular representation and property prediction. Drug Discovery Today, 103373.
[7] Shugang Zhang, Mingjian Jiang, Shuang Wang, Xiaofeng Wang, Zhiqiang Wei and Zhen Li. (2021). SAG-DTA: Prediction of Drug–Target Affinity Using Self-Attention Graph Network. International Journal of Molecular Sciences, 22(16), 8993.
[8] Shuang Wang, Mingjian Jiang, Shugang Zhang, Xiaofeng Wang, Qing Yuan, Zhiqiang Wei and Zhen Li. (2021). MCN-CPI: Multiscale Convolutional Network for Compound–Protein Interaction Prediction. Biomolecules, 11(8), 1119.
[9] Wenjian Ma, Shugang Zhang, Zhen Li, Mingjian Jiang, Shuang Wang, Nianfan Guo, Yuanfei Li, Xiangpeng Bi, Huasen Jiang and Zhiqiang Wei. (2023). Predicting Drug-Target Affinity by Learning Protein Knowledge From Biological Networks. IEEE Journal of Biomedical and Health Informatics, 27(4), 2128-2137.
[10] Wenjian Ma, Shugang Zhang, Zhen Li, Mingjian Jiang, Shuang Wang, Weigang Lu, Xiangpeng Bi, Huasen Jiang, Henggui Zhang and Zhiqiang Wei. (2022). Enhancing protein function prediction performance by utilizing AlphaFold-predicted protein structures. Journal of Chemical Information and Modeling, 62(17), 4008-4017.
[11] Shuang Wang, Tao Song, Shugang Zhang, Mingjian Jiang, Zhiqiang Wei and Zhen Li. (2022). Molecular substructure tree generative model for de novo drug design. Briefings in bioinformatics, 23(2), bbab592.
[12] Xiaofeng Wang, Zhen Li, Mingjian Jiang, Shuang Wang, Shugang Zhang, and Zhiqiang Wei. (2019). Molecule property prediction based on spatial graph embedding. Journal of chemical information and modeling, 59(9), 3817-3828.
教学成果
指导学生获得蓝桥杯、山东省大学生计算机设计大赛获得多项竞赛奖励。